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Communication | Regular issue | Vol 68, No. 2, 2006, pp.233-236
Published online, 20th December, 2005
DOI: 10.3987/COM-05-10632
Synthesis of (S)-Plakolide A and Revision of the Absolute Stereochemistry of the Natural (-)-Plakolide A

Masaru Kanayama, Keiji Nishiwaki, and Keizo Matsuo*

*Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1, Kowakae, Higashi-Osaka 577-8502, Japan


(S)-Plakolide A, a γ-lactone from the marine sponge Plakortis sp., was synthesized starting from (S)-lactic acid by applying the chiral self-reproduction procedure. As the results of the synthetic research, the absolute stereochemistry of the natural product should be revised to R.