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Paper | Regular issue | Vol 68, No. 3, 2006, pp.483-493
Published online, 31st January, 2006
DOI: 10.3987/COM-05-10652
Asymmetric Synthesis of Flindersiachromanone Using Lipase-catalyzed Reaction

Masashi Kawasaki,* Hikaru Yoshikai, Hiroko Kakuda, Naoki Toyooka, Akira Tanaka, Michimasa Goto, and Tadashi Kometani

*Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan

Abstract

The (R)- and (S)-enantiomers of flindersiachromanone (2-(2-phenylethyl)-4-chromanone) were synthesized from the enantiomerically pure 1-phenyl-5-hexen-3-ol obtained via the lipase-catalyzed enantioselective transesterification.