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Communication | Regular issue | Vol 68, No. 3, 2006, pp.453-457
Published online, 21st February, 2006
DOI: 10.3987/COM-05-10661
Novel Method for the Synthesis of β-Lactams by the Reaction of α-Bromocarboxylic Acids with Imines Mediated by Triphenylphosphine

Satoshi Kikuchi and Yukihiko Hashimoto*

*Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

Abstract

The useful and simple method for the formation of the β-lactams by the reaction between α-bromo carboxylic acids and imines is described. This reaction was effectively mediated by triphenylphosphine or polystyryl-diphenylphosphine to give the β-lactams in good yields with high trans-selectivity.