Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 66, No. 1, 2005, pp.107-109
Published online, 21st October, 2005
DOI: 10.3987/COM-05-S(K)44
A Concise Enantioselective Synthesis of (+)-α-Conhydrine

Kazuhiro Nagata, Yosuke Toriizuka, and Takashi Itoh*

*School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan


A short step synthesis of (+)-α-conhydrine was achieved employing a kinetic resolution of 2-(1-hydroxypropyl)pyridine with lipase PS and a chelation-controlled diastereoselective reduction of pyridine ring as key reactions.