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Communication | Special issue | Vol 66, No. 1, 2005, pp.107-109
Published online, 21st October, 2005
DOI: 10.3987/COM-05-S(K)44
A Concise Enantioselective Synthesis of (+)-α-Conhydrine

Kazuhiro Nagata, Yosuke Toriizuka, and Takashi Itoh*

*School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan

Abstract

A short step synthesis of (+)-α-conhydrine was achieved employing a kinetic resolution of 2-(1-hydroxypropyl)pyridine with lipase PS and a chelation-controlled diastereoselective reduction of pyridine ring as key reactions.