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Note | Special issue | Vol 66, No. 1, 2005, pp.639-644
Published online, 21st October, 2005
DOI: 10.3987/COM-05-S(K)59
Spiro Crown Ethers Bearing (S)-1,1’-Spirobiindanes as Chiral Backbones

Kohji Yonezawa, Mahesh L. Patil, Hiroaki Sasai, and Shinobu Takizawa*

*The Institute of Scientific and Industrial Research, Osaka University, 8-1, Mihogaoka, Ibaraki, Osaka 567-0047, Japan

Abstract

The synthesis of spiro chiral crown ethers ((S)-1a) and ((S)-1b) has been achieved. The combination of (S)-1a and KOH promoted the asymmetric alkylation of glycine derivative (2) with moderate enantioselectivity.