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Communication | Special issue | Vol 66, No. 1, 2005, pp.161-166
Published online, 11th November, 2005
DOI: 10.3987/COM-05-S(K)67
Syntheses and Biological Activities of Structurally Stiff Rhodacyanines as Novel Antimalarial Candidates

Kiyosei Takasu,* Daiki Morisaki, Marcel Kaiser, Reto Brun, and Masataka Ihara*

*Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan

Abstract

New classes of rhodacyanine as structurally stiff derivatives were designed and synthesized. The synthetic compounds were evaluated the antimalarial activity and cytotoxicity in vitro.