Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Special issue | Vol 67, No. 2, 2006, pp.763-768
Published online, 14th October, 2005
DOI: 10.3987/COM-05-S(T)40
Palladium-catalyzed Arylation of Diisopropyl Malonate Applied to the Efficient Synthesis of the Selective MMP Inhibitor 5-(4-Phenoxyphenyl)-5-[4-(2-pyrimidinyl)-1-piperazinyl]barbituric Acid

Stanley Hutchings, Wen Liu, and Roumen Radinov*

*Chemical Synthesis Department, Hoffmann - La Roche Inc., Building 66, 340 Kingsland Street, Nutley, NJ 07110-1199, U.S.A.


An efficient synthesis of the highly selective MMP inhibitor 5-(4-phenoxyphenyl)-5-[4-(2-pyrimidinyl)-1-piperazinyl]barbituric acid is reported. The title compound was prepared in three steps and 72% overall yield from 4-bromophenyl phenyl ether via an improved arylation of diisopropyl malonate.