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Communication | Special issue | Vol 67, No. 2, 2006, pp.519-522
Published online, 30th September, 2005
DOI: 10.3987/COM-05-S(T)52
Synthesis of Bicyclic Cyclopropylamines from Amino Acid Derivatives

Catherine A. Faler, Bin Cao, and Madeleine M. Joullié*

*Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, U.S.A.

Abstract

The synthesis of novel [3.1.0] bicyclic cyclopropylamines from differently substituted amino acids using Ti(II)-mediated coupling and the extension of this methodology to provide [4.1.0] systems is described.