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Communication | Special issue | Vol 67, No. 2, 2006, pp.549-554
Published online, 14th October, 2005
DOI: 10.3987/COM-05-S(T)65
Synthesis of 3-Oxoazacyclohept-4-enes by Ring-closing Metathesis. Application to the Synthesis of an Inhibitor of Cathepsin K

Catherine Taillier, Thomas Hameury, Véronique Bellosta,* and Janine Cossy*

*Laboratoire de Chemie Organique, Ecole Supérieure de Physique & Chemie Industrielle, 10 rue Vauquelin, 75231 Paris Cedex 05, France

Abstract

The ring-closing metathesis allows the formation of 3-oxoazacyclohept-4-enes from but-3-enamine. By using this methodology, the synthesis of an inhibitor of cathepsin K was achieved in 10 steps from but-3-enamine.