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Note | Regular issue | Vol 68, No. 4, 2006, pp.801-806
Published online, 3rd March, 2006
DOI: 10.3987/COM-06-10669
Synthesis of 1H-Pyrazolo[4’,3’:5,6]pyrimido[2,1-a]isoindol-4(10H)-ones. Derivatives of a New Ring System

Abolghasem Davoodnia, Mehdi Bakavoli,* Ali Vahedinia, Mohammad Rahimizadeh, and Mina Roshani

*Department of Chemistry, School of Sciences, Islamic Azad University, Mashhad 91775-1435, Iran

Abstract

Several derivatives of the new pyrazolo[4’,3’:5,6]pyrimido[2,1-a]isoindolone ring system (4) have been prepared through heterocyclization of 2-chloromethylbenzoyl chloride (1) with appropriately substituted 5-amino-1H-pyrozole-4-carbonitriles (2). The reaction intermediate inden-2-yl-1-phenyl-pyrazole-4-carbonitrile (3), on subjection to acid or base, underwent hydrolysis and cyclocondensation simultaneously to afford the tetracyclic compound (4).