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Note | Regular issue | Vol 68, No. 7, 2006, pp.1443-1449
Published online, 12th May, 2006
DOI: 10.3987/COM-06-10753
Polyphosphoric Acid-Induced Construction of Quinazolinone Skeleton from 1-(3,4-Dimethoxyphenyl)-3-phenylurea and Carboxylic Acids

Iliyan Ivanov,* Stoyanka Nikolova, Ekaterina Kochovska, and Stela Statkova-Abeghe

*Department of Organic Chemistry, University of Plovdiv, 24, Tsar Assen Str. 4000 Plovdiv, Bulgaria

Abstract

A general synthesis of a series 4-substituted 3,4-dihydro-2(1H)-quinazolinones (7) included polyphosphoric acid (PPA)-induced cyclization with carboxylic acids. Modification at the 4-position of the quinazolinone skeleton was best achieved by variation of carboxylic acids. Starting 1-(3,4-dimethoxyphenyl)-3-phenylurea (3) was prepared from the phenylisocyanate and 3,4-dimethoxyaniline.