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Communication | Regular issue | Vol 68, No. 8, 2006, pp.1565-1569
Published online, 23rd June, 2006
DOI: 10.3987/COM-06-10771
The Ideal Synthetic Method Aimed at the Leads for an α2-Blocker, an Inhibitor of Blood Platelet Aggregation, and an Anti-osteoporosis Agent

Masanori Somei,* Takako Iwaki, Fumio Yamada, Yoshio Tanaka, Koki Shigenobu, Katsuo Koike, Nobuo Suzuki, and Atsuhiko Hattori

*Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan

Abstract

According to the definition of the ideal synthetic method, an example aimed at the leads for an α2-blocker, an inhibitor of platelet aggregation, and an anti-osteoporosis agent is established starting from tryptamine. The originality rate, the intellectual property, and the application potential factors of the method are 71, 54, and 100, respectively. The method employs only conventional reagents and reaction conditions without using any protecting groups.