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Paper | Regular issue | Vol 68, No. 8, 2006, pp.1651-1658
Published online, 2nd June, 2006
DOI: 10.3987/COM-06-10778
Ionic Liquid in Organic Synthesis: The Pictet-Spengler Reaction

Huey-Min Wang,* Rei-Sheu Hou, Hsin-Yu Huang, and Ling-Ching Chen*

*Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, 100 Shin Chuan 1st Rd., Kaohsiung 80708, Taiwan, R.O.C.

Abstract

We have demonstrated the use of the room temperature ionic liquid, 1-butyl-3-methylimidazoliumhexafluorophosphate ([bmim]PF6), as an environmentally benign solvent for the preparation of 2-benzenesulfonyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid ethyl ester derivatives through Pictet-Spengler reaction using phenyliodine(III) bis(trifluoroacetate) (PIFA) under mild conditions.