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Paper | Regular issue | Vol 68, No. 11, 2006, pp.2285-2299
Published online, 5th September, 2006
DOI: 10.3987/COM-06-10844
Synthesis, Crystal Structure Determination and Antiproliferative Evaluation of Novel Benzazoyl Benzamides

Kristina Starcevic, Irena Caleta, Dominik Cincic, Branko Kaitner, Marijeta Kralj, Katja Ester, and Grace Karminski-Zamola

*Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, Marulicev trg 20, HR-10000 Zagreb, Croatia

Abstract

A series of benzazoyl-benzamides containing different substituents (7-17) were synthesized by condensation of 2-aminobenzazole derivatives (3a-6) with p-substituted benzoyl chlorides. All compounds were characterized by IR, 1H and 13C NMR, MS and elemental analysis. Crystal structure was determined for the compound (9). Some of the new synthesized compounds (7-17) were screened for antitumor activities. Based on presented in vitro screening results we may conclude that compounds (10, 15a, 15b and 16) showed accentuated cell growth inhibitory activity.