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Communication | Regular issue | Vol 68, No. 11, 2006, pp.2247-2252
Published online, 22nd September, 2006
DOI: 10.3987/COM-06-10863
Synthesis of 4-Arylpyrazoles via PdCl2(dppf)-Catalyzed Cross Coupling Reaction with Grignard Reagents

Hayato Ichikawa,* Yuuki Ohno, Yoshihide Usami, and Masao Arimoto

*Osaka University of Pharmaceutical Sciences, Nasahara Takatsuki, Osaka 569-1141, Japan

Abstract

4-Aryl-1-tritylpyrazoles were prepared from the cross coupling reaction of aryl Grignard reagents with 4-bromo-1-tritylpyrazoles in the presence of 0.2 mol% PdCl2(dppf) as catalyst. To deprotect the trityl group, 4-phenyl-1-tritylpyrazole was reacted with TFA to produce 4-arylpyrazole in quantitative yield.