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Note | Regular issue | Vol 68, No. 12, 2006, pp.2635-2645
Published online, 2nd November, 2006
DOI: 10.3987/COM-06-10886
Efficient New Approach for the Synthesis of N,N-Dialkylamino-1,2,4-triazoles

Qiang Zhang,* Youyi Peng, and William J. Welsh*

*Department of Pharmacology and the Informartics, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, New Jersey 00854, U.S.A.


A series of 3-N,N-dialkylamino-4,5-diaryl-1,2,4-triazoles were synthesized in high yield under mild reaction conditions by coupling functionalized arylmagnesiums with isothiocyanates and cyclization with Viehe’s salts. No selective thionation reaction was required for the preparation of carbamoyl derivatives.