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Paper | Regular issue | Vol 71, No. 2, 2007, pp.269-280
Published online, 29th December, 2006
DOI: 10.3987/COM-06-10899
The Study of Cyclization of N-Acylphenacyl Anthranilates with Ammonium Salts under Various Conditions

Pavel Hradil,* Martin Grepl, Jan Hlavac, and Antonin Lycka

*Department of Organic Chemistry, Palacky University, Trida Svobody 8, 77146 Olomouc, Czech Republic

Abstract

N-Acylphenacyl anthranilates were heated with ammonium salts in organic acid or NMP, and formation of various heterocyclic compounds was observed. Reaction results are strongly influenced by reaction conditions. The most interesting are imidazole derivatives with various anelated rings.