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Note | Regular issue | Vol 71, No. 2, 2007, pp.389-398
Published online, 19th December, 2006
DOI: 10.3987/COM-06-10909
Efficient Method for the Synthesis of Dibenzo[b,f]thiepin-10-ones under Mild Conditions

Qiang Zhang,* Youyi Peng, and William J. Welsh*

*Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine & Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, U.S.A.

Abstract

A mild and efficient method to synthesize dibenzo[b,f]thiepin-10-one derivatives was achieved, with key steps of PPE mediated cyclization of seven-member ring and selective ketone α bromination with CuBr2. Reaction of α alkylation and arylation of ketones were also optimized to finish the synthesis with good overall yield.