Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 71, No. 1, 2007, pp.117-134
Published online, 1st December, 2006
DOI: 10.3987/COM-06-10914
Synthesis of 5-Chloromethylene Hydantoins and Thiohydantoins

Timothy A. Cernak and James L. Gleason*

*Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec H3A 2K6, Canada

Abstract

5-Chloromethylene hydantoins were prepared by condensation of ureas with chloropyruvic acid. 5-Chloromethylene thiohydantoins were prepared by chlorination of dehydroalanines followed by condensation with thiophosgene. Convenient methods for formation of aminomethylene hydantoins and thiohydantoins using N,N,N’,N’-tetramethylformamidinium chloride are also reported.