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Note | Regular issue | Vol 71, No. 2, 2007, pp.459-465
Published online, 29th December, 2006
DOI: 10.3987/COM-06-10953
Concise Synthesis of Diarylmethyl-1H-pyrroles

Meng-Yang Chang,* Tsun-Cheng Wu, and Ya-Jung Ko

*Department of Applied Chemistry, National University of Kaohsiung, No. 700 Kaohsiung University Rd., Nan-Tzu District, Kaohsiung 811, Taiwan, R.O.C.


An easy and straightforward synthesis of diarylmethyl-1H-pyrroles has been established starting from trans-(2S,4R)-4-hydroxyproline by the key combination of Grignard addition/aromatization.