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Note | Regular issue | Vol 71, No. 4, 2007, pp.925-932
Published online, 9th February, 2007
DOI: 10.3987/COM-06-10970
An Efficient Two-Step Synthesis of 4-Methyl-1,2,3,5,6,10b-hexahydropyrimido[5,4-c]quinoline-2,5-diones via Biginelli Reaction

Lhassane Ismaili, Sophie Ubaldi, Jean-Francois Robert, Alain Xicluna, and Bernard Refouvelet*

*Equipe Sciences séparatives et Biopharmaceutique (2SB), Laboratory of medicinal chemistry, Faculty of Pharmacy, 4, place Saint Jacques - 25030 Besançon Cedex, France

Abstract

An efficient two-step synthesis of 4-methyl-1,2,3,5,6,10b-hexahydropyrimido[5,4-c]quinoline-2,5-diones is presented. It consists of the reactions of appropriate aldehyde, urea and ethyl acetoacetate according to Biginelli reaction, followed by cyclisation with ammonia.