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Communication | Special issue | Vol 72, No. 1, 2007, pp.163-166
Published online, 26th January, 2007
DOI: 10.3987/COM-06-S(K)39
Versatile Synthesis of 2,2-Disubstituted Indolinones via Protected Indolones Generated by One-Pot Multi-oxidation of 2-Substituted Indoles

Matthew J. Buller, Travis G. Cook, and Yoshihisa Kobayashi*

*Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0343, U.S.A.


The discovery of expeditious multi-oxidation of indoles to masked indolones led us to the development of a versatile synthetic method to access a variety of 2,2-disubstituted indolinones bearing two different substituents.