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Communication | Special issue | Vol 72, No. 1, 2007, pp.181-185
Published online, 29th December, 2006
DOI: 10.3987/COM-06-S(K)44
Total Synthesis of Citrafungin A

Mumen F. A. Amer, Keisuke Takahashi, Jun Ishihara, and Susumi Hatakeyama*

*Department of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan


Citrafungin A, a member of the alkyl citrate class of natural products, was synthesized for the first time employing a convergent approach involving aldol reaction of (R)-4-((1E,5Z)-tetradeca-1,5-dienyl)-γ-butyrolactone with tert-butyl 4-(p-methoxybenzyloxy)-2-oxobutanoate and installation of (2R,3S)-tri-tert-butyl isocitrate.