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Communication | Special issue | Vol 72, No. 1, 2007, pp.187-190
Published online, 6th February, 2007
DOI: 10.3987/COM-06-S(K)51
Hilbert-Johnson Reaction under High Pressure: A Facile Preparation of 2-Pyridones

Kiyoshi Matsumoto,* Yukio Ikemi, Machiko Suda, Hirokazu Iida, and Hiroshi Hamana

*Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 15-8 Shiomi-cho, Choshi, Chiba 288-0025, Japan


For the first time, a facile synthesis of 2-pyridones utilizing a classical Hilbert-Johnson reaction of 2-methoxypyridines with haloalkanes under high pressure has been achieved. The reactions were sensitive to steric hindrance of haloalkanes.