Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 72, No. 1, 2007, pp.91-94
Published online, 22nd December, 2006
DOI: 10.3987/COM-06-S(K)7
A New Method for Efficient Coupling of Indole and Epoxide Catalyzed with Yb(OTf)3, and Application to the Total Synthesis of Kurasoin B

Satoshi Tsuchiya, Toshiaki Sunazuka, Tatsuya Shirahata, Tomoyasu Hirose, Eisuke Kaji, and Satoshi Omura*

*Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan


The Yb(OTf)3 catalyzed reaction between indole and epoxide in simple and mild condition was developed. This method is suitable for gram-scale synthesis of 3-indolelactic acid derivatives. The asymmetric synthesis of kurasoin B was achieved using chiral 3-indolelactic acid methyl ester as the starting material.