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Paper | Special issue | Vol 69, No. 1, 2006, pp.259-269
Published online, 11th August, 2006
DOI: 10.3987/COM-06-S(O)26
1-Hydroxyyohimbine and Its Derivatives: New Potent α2-Blockers for the Treatment of Erectile Dysfunction

Masanori Somei,* Koichi Noguchi, Katsumasa Yoshino, Koichiro Mori, Mamiko Asada, Fumio Yamada, Yoshio Tanaka, Koki Shigenobu, and Katsuo Koike

*Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan


1-Hydroxyyohimbine and its various derivatives are prepared for the first time. These novel compounds are found to be potent α2-blockers comparable to yohimbine itself.