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Communication | Special issue | Vol 69, No. 1, 2006, pp.43-48
Published online, 7th March, 2006
DOI: 10.3987/COM-06-S(O)4
■ 3,4,5,6-Tetrasubstituted 2-Pyridone Synthesis via Nucleophilic Addition of Active Methine Compounds to Dialkynyl Imines Directed to the Synthesis of (-)-A58365A

Iwao Hachiya, Shiho Fukushima, and Makoto Shimizu*

*Department of Chemistry for Materials, Mie University, Tsu, Mie 514-8507, Japan

Abstract

3,4,5,6-Tetrasubstituted-2-pyridone synthesis via nucleophilic addition of active methine compounds to dialkynyl imines directed to the synthesis of (-)-A58365A has been developed. The reaction of active methine compounds such as malonic esters or β-keto esters to dialkynyl imines provided 3,4,5,6-tetrasubstituted-2-pyridones in moderate to good yields.