Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 71, No. 4, 2007, pp.911-918
Published online, 23rd February, 2007
DOI: 10.3987/COM-07-11003
Chemoselective Oxidation of 6-Hydroxyalkylpteridine and Its Application to Synthesis of 6-Acyl-7,8-dihydropteridine

Sudhir S. Landge, Kazunari Kudoh, Yuri Yamada, and Shizuaki Murata*

*Graduate School of Environmental Studies, Nagoya University, Chikusa Nagoya 464-8601 Japan

Abstract

Alcohol-selective oxidation of 6-1’-hydroxyalkylpteridines catalyzed by ruthenium (IV), RuO4-, gives 6-acylpteridines in high yields. Partial reduction of the products affords 6-acyl-7,8-dihydropteridine derivatives, such as a lipophilic derivative of sepiapterin, deoxysepiapterin, and sepiapterin-C.