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■ New Flavanone Oligoglycosides, Theaflavanosides I, II, III, and IV, with Hepatoprotective Activity from the Seeds of Tea Plant (Camellia sinensis)

Ning Li, Toshio Morikawa, Hisashi Matsuda, Kiyofumi Ninomiya, Xian Li, and Masayuki Yoshikawa*

*Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan

Abstract

Four new flavanone oligoglycosides, theaflavanosides I, II, III, and IV, were isolated from the seeds of Camellia sinensis. The structures of theaflavanosides were elucidated on the basis of chemical and physicochemical evidence. Among them, theaflavanoside III was found to show hepatoprotective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes.