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Paper | Regular issue | Vol 71, No. 8, 2007, pp.1765-1777
Published online, 25th May, 2007
DOI: 10.3987/COM-07-11060
Synthesis and Antimicrobial Evaluation of Novel Pyrazolo[1,5-a]pyrimidine, Triazolo[1,5-a]pyrimidine and Pyrimido[1,2-a]benzimidazole Derivatives

Mohamed R. Shaaban, Tamer S. Saleh, and Ahmad M. Farag*

*Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt


The applicability and synthetic potency of E-1-(1-methylbenzimidazol- 2-yl)-3-N,N-dimethylaminoprop-2-enone towards some nitrogen nucleophiles was investigated as a convenient route for the synthesis of some novel aminopyrimidine, pyrazolo[1,5-a]pyrimidine, triazolo[1,5-a]pyrimidine, pyrimido[1,2-a]benzimidazole, and pyrido[2,3-d]pyrimidine derivatives. Some of the newly synthesized compounds were tested in vitro for their antibacterial and antifungal activities, and showed promising results.