HETEROCYCLES
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Obituary
Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Paper | Regular issue | Vol 71, No. 8, 2007, pp.1801-1806
Published online, 22nd May, 2007■ Synthesis of Arnoamine B and Related Compounds
Published online, 22nd May, 2007
DOI: 10.3987/COM-07-11074
■ Synthesis of Arnoamine B and Related Compounds
Shinsuke Nakahara,* Akinori Kubo, Yuzuru Mikami,* and Hiroki Mitani
*Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan
Abstract
The synthesis of arnoamine B (4), which inhibits the catalytic activity of topoisomerase II and exhibits selective cytotoxicity against human tumor cell lines, was achieved in four steps from 4-bromo-8-methoxy-6-methyl-5-nitroquinoline (6). The related compounds 11~14 were also synthesized, and the antimicrobial activities of 4 and its seven related compounds 6, 8, 9, and 11~14 were investigated.
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