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Obituary
Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Communication | Regular issue | Vol 71, No. 8, 2007, pp.1715-1721
Published online, 22nd May, 2007■ Design and Synthesis of Novel Ring-Expanded Arbekacin Analogues
Published online, 22nd May, 2007
DOI: 10.3987/COM-07-11081
■ Design and Synthesis of Novel Ring-Expanded Arbekacin Analogues
Nobuto Minowa,* Yukiko Hiraiwa, Yoshihisa Akiyama, Kazunori Maebashi, Takayuki Usui, and Daishiro Ikeda
*Pharmaceutical Research Center, Meiji Seika Kaisha Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan
Abstract
Novel homologated aminoglycosides having a seven-membered ring were designed and synthesized by treatment of 5-keto arbekacin with diazomethane in CH2Cl2-Et2O. The ring-expanded arbekacin analogue showed good antibacterial activity against Staphylococcus aureus and Escherichia coli including aminoglycoside-resistant bacterial strain.
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