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Communication | Regular issue | Vol 71, No. 8, 2007, pp.1715-1721
Published online, 22nd May, 2007
DOI: 10.3987/COM-07-11081
Design and Synthesis of Novel Ring-Expanded Arbekacin Analogues

Nobuto Minowa,* Yukiko Hiraiwa, Yoshihisa Akiyama, Kazunori Maebashi, Takayuki Usui, and Daishiro Ikeda

*Pharmaceutical Research Center, Meiji Seika Kaisha Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan


Novel homologated aminoglycosides having a seven-membered ring were designed and synthesized by treatment of 5-keto arbekacin with diazomethane in CH2Cl2-Et2O. The ring-expanded arbekacin analogue showed good antibacterial activity against Staphylococcus aureus and Escherichia coli including aminoglycoside-resistant bacterial strain.