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Note | Regular issue | Vol 71, No. 10, 2007, pp.2263-2271
Published online, 3rd July, 2007
DOI: 10.3987/COM-07-11123
Synthesis of 1,3-Diepi-ED-71, a Biologically Important Diastereomer of 1α,25-Dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71)

Ayako Fujiyama, Mai Kaneko, Keisuke Takahashi, Jun Ishihara, Susumi Hatakeyama, and Noboru Kubodera*

*Chugai Pharmaceutical Co., Ltd., 2-1-1, Nihonbashi-Muromachi, Chuo-ku, Tokyo 103-8324, Japan

Abstract

The synthesis of biologically important 1,3-diepi-ED-71, a diastereomer of 1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D3 (ED-71) at the 1-position and 3-position of the A-ring using Trost’s coupling methodology is described.