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Paper | Regular issue | Vol 71, No. 11, 2007, pp.2441-2447
Published online, 8th August, 2007
DOI: 10.3987/COM-07-11140
Three New ent-Kauranoids from Isodon phyllostachys

Xian Li, Jianxin Pu, Shenghong Li, Shengxiong Huang, Zhiying Weng, Quanbin Han, and Handong Sun*

*State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P.R. China

Abstract

Three new ent-kaurane diterpenoids, phyllostacins C-E (1-3), together with six known analogues, oridonin (4), ponicidin (5), effusanin A (6), rabdoternin E (7), rabdoternin F (8), and macrocalyxoformin E (9), were isolated from the aerial parts of Isodon phyllostachys. The structures of compounds (1-3) were determined on the basis of spectroscopic methods including extensive 1D and 2D NMR analysis. All compounds were evaluated for their inhibitory activity against K562, HL60 and HepG2 (hepatoma) cell lines.