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Paper | Regular issue | Vol 71, No. 11, 2007, pp.2449-2456
Published online, 3rd August, 2007
DOI: 10.3987/COM-07-11142
Synthesis of Aza-Analog of N-Methylated Acycloformycin A

Mariusz Mojzych* and Andrzej Rykowski

*Department of Chemistry, University of Podlasie, 08-110 Siedlce, Poland

Abstract

Starting from 3-methyl-5-methylsulfanyl-1H-pyrazolo[4,3-e][1,2,4]- triazine (1) by reaction with methyl iodide, subsequent oxidation, ipso-substitution with hydrazine and reaction with yellow mercury (II) oxide 1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazine (14) is prepared. Further radical bromination and treatment with ethylene glycol in the presence of potassium carbonate afforded 3-(2-hydroxy-ethoxymethyl)-1-methyl-1H-pyrazolo[4,3-e]- [1,2,4]triazine (16) as aza-analog of N-methylated acycloformycin A.