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Paper | Regular issue | Vol 75, No. 1, 2008, pp.87-93
Published online, 20th September, 2007
DOI: 10.3987/COM-07-11182
An Efficient Three-Component, One-Pot Synthesis of New Pyrimido[4,5-d]pyrimidine-2,4-diones

Minoo Dabiri, Seyyedeh Cobra Azimi, Hamid Arvin-Nezhad, and Ayoob Bazgir*

*Chemistry Department, Faculty of Sciences, Shahid Beheshty University, P. O. Box 19395-4716 Tehran, Iran

Abstract

A new pyrimido[4,5-d]pyrimidine-2,4-(1H,3H,5H,8H)-dione derivatives have been synthesized in good yields in a three-component, one-pot, and efficient process by condensation reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride under solvent-free conditions.