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Note | Regular issue | Vol 75, No. 1, 2008, pp.183-188
Published online, 28th September, 2007
DOI: 10.3987/COM-07-11206
A Convenient One-Pot Preparation of N-Substituted 4-Phenylpiperidines

Shigehiro Asano and Hitoshi Ban*

*Dainippon Sumitomo Pharmaceuticals Co., Ltd., Enoki 33-94, Suita, Osaka 564, Japan


N-Substituted 4-phenylpiperidines were readily synthesized by one-pot cyclization of diols with amines via bis-triflate intermediates. The new synthesis under mild conditions gave various N-substituted 4-phenylpiperidines in moderate to good yields.