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Paper | Regular issue | Vol 75, No. 4, 2008, pp.887-897
Published online, 11th January, 2008
DOI: 10.3987/COM-07-11286
Synthesis and Antimicrobial Evaluation of Some New Pyrimidine Derivatives

Nabila A. Kheder, Yahia N. Mabkhot, and Ahmad M. Farag*

*Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt

Abstract

The utility of ethyl 6-methyl-2-oxo-4-phenyl-1,2-dihydropyrimidine- 5-carboxylate (1) in the synthesis of some new pyrido[1,2-f]pyrimidine, pyrazolo[3,4-b]pyrido[1,2-f]pyrimidine, 6-(4-substituted styryl)pyrimidine, pyrido[4,3-d]pyrimidine, pyrimido[5,4-d]pyridazine and substituted-6-(thien-2-yl)pyrimidine derivatives is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out.