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Note | Regular issue | Vol 75, No. 6, 2008, pp.1479-1488
Published online, 15th February, 2008
DOI: 10.3987/COM-07-11311
A Convenient Synthesis of Novel Series of 4-Cyclohexyl-2-substituted [1,2,4]Triazolo[1,5-a]quinazolin-5(4H)-ones. Novel Isomers of H1 Antihistaminic Activite Agents

Ahmad S. Shawali,* Hamdi M. Hassaneen, and Nabil K. Shurrab

*Department of Chemistry, Faculty of Science, University of Cairo, Giza, 12613, Egypt

Abstract

A novel series of 2,4-disubstituted-1,2,4-triazolo[1,5-a]-quinazolin-5(4H)-ones were prepared by Dimroth rearrangement of their respective isomers namely 1,4-disubstituted[1,2,4]triazolo[4,3-a]-quinazolin-5(4H)-ones. The latter were prepared via new synthetic strategy based on 1,5-elecrocyclization of the respective N-(4-oxo-3-cyclohexylquinazolin-2-yl)nitrilimines.