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Communication | Special issue | Vol 76, No. 1, 2008, pp.133-136
Published online, 25th January, 2008
DOI: 10.3987/COM-07-S(N)6
Copper-Catalyzed N-Arylation Reaction of 2-Azabicyclo[2.2.1]hept-5-en-3-one with Arylboronic Acids under Microwave Irradiation

Takumi Abe, Hiroyuki Takeda, Koji Yamada, and Minoru Ishikura*

*Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan

Abstract

Copper-catalyzed N-arylation reaction of 2-azabicyclo[2.2.1]hept-5-en-3-one (ABH) with arylboronic acids was successively performed in the presence of KOH and trimethylamine-N-oxide under microwave irradiation.