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Note | Special issue | Vol 74, No. 1, 2007, pp.927-930
Published online, 31st May, 2007
DOI: 10.3987/COM-07-S(W)1
Synthesis of Artekeiskeanin A: A New Coumarin Monoterpene Ether from Artemisia keiskeana

Dominick Maes, Kris Van Syngel, and Norbert De Kimpe*

*Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium


The first total syntheses of artekeiskeanin A, a natural coumarin monoterpene ether from Artemisia keiskeana, and 7-geranyloxy-6-methoxycoumarin, a coumarin monoterpene ether with antifungal and antitumor properties, are reported. Key step in the synthesis of artekeiskeanin A is the stereoselective oxidation of the geranyloxy side chain of 7-geranyloxy-6-methoxycoumarin under microwave irradiation.