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Note | Special issue | Vol 74, No. 1, 2007, pp.931-936
Published online, 27th April, 2007
DOI: 10.3987/COM-07-S(W)2
Cell Growth and Cell Cycle Inhibitory Activities of 20-Epidiosgenyl Saponin from Calamus insignis

Takashi Ohtsuki, Noriko Kaneko, Takashi Koyano, Thaworn Kowithayakorn, Nobuo Kawahara, Yukihiro Goda, and Masami Ishibashi*

*Graduate School of Pharmaceutical Science, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan

Abstract

A new 20 epi-diosgenyl saponin (1) was isolated from the stems of Calamus insignis (Palmae) by bioassay guided purification. The chemical structure of 1 was established on the basis of spectroscopic analysis and chemical means. Compound 1 showed cell growth inhibitory activity against HeLa cells (IC50; 5.1 μM) and exhibited a cell cycle inhibitory effect at the G2/M stage at the concentration of 2.9 μM by flow cytometric analysis.