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Paper | Special issue | Vol 74, No. 1, 2007, pp.411-420
Published online, 4th September, 2007
DOI: 10.3987/COM-07-S(W)20
Chemistry of Tetrahydroisoquinoline Antitumor Natural Products: Preparation and Antitumor Activity of Analogues of Cribrostatin 4

Emi Saito, Naomi Daikuhara, and Naoki Saito*

*Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

Abstract

The two-step transformation of saframycin G (9) into saframycin F (1b) and renieramycin O (11) into renieramycin Q (2) is described, along with the results of cytotoxicity studies.