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Paper | Special issue | Vol 74, No. 1, 2007, pp.265-271
Published online, 1st May, 2007
DOI: 10.3987/COM-07-S(W)3
Synthesis of Alternariol through an Intramolecular Biaryl Coupling Reaction Using Palladium Reagent

Hitoshi Abe,* Tomoko Fukumoto, Yasuo Takeuchi, and Takashi Harayama*

*Faculty of Pharmaceutical Science, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan


The facile synthesis of alternariol was accomplished through an intramolecular biaryl coupling reaction of the phenyl benzoate derivative, which was prepared by the simple esterification of the corresponding phenol and benzoic acid using a palladium reagent. The regioselectivity during the biaryl coupling reaction was also investigeted.