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Paper | Special issue | Vol 74, No. 1, 2007, pp.545-552
Published online, 21st September, 2007
DOI: 10.3987/COM-07-S(W)32
Facile One-Pot Synthesis of Functionalized Acetylenes from Aryl and Heteroaryl Aldehydes Using Lithium Trimethylsilyldiazomethane

Yoshiyuki Hari, Koji Date, Toyohiko Aoyama*

*Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan


The reaction of aryl and heteroaryl aldehydes with lithium trimethylsilyldiazomethane followed by treatment with n-BuLi and then electrophiles in one-pot efficiently afforded functionalized acetylenes.