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Paper | Special issue | Vol 74, No. 1, 2007, pp.649-660
Published online, 16th October, 2007
DOI: 10.3987/COM-07-S(W)49
A Facile Synthesis of 1,2-Dihydroisoquinolines by Three-Component Reaction

Kentaro Iso, Salprima Yudha S., Menggenbateer, and Naoki Asao*

*Graduate School of Science, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan

Abstract

1,2-Dihydroisoquinoline frameworks are constructed efficiently by three-component reactions with ortho-alkynylbenzaldehydes, primary amines, and pronucleophiles under mild conditions.