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Paper | Special issue | Vol 74, No. 1, 2007, pp.849-853
Published online, 16th November, 2007
DOI: 10.3987/COM-07-S(W)77
Seragadine A, a β-Carboline Alkaloid from Marine Sponge

Kohei Nozawa, Masashi Tsuda, Takaaki Kubota, Jane Fromont, and Jun’ichi Kobayashi*

*Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan

Abstract

A new quaternary β-carboline alkaloid, seragadine A (1), and three known related alkaloids (2 ~ 4) have been isolated from an Okinawan Haplosclerida sponge (SS-1022). The structure of 1 was determined by the spectroscopic data and its synthesis.