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Paper | Regular issue | Vol 75, No. 7, 2008, pp.1681-1694
Published online, 4th March, 2008
DOI: 10.3987/COM-08-11350
A New Route for the Synthesis of Linezolid Mimetic 3,4-Disubstituted Oxazolidin-2-one Derivatives

Fumiko Fujisaki, Nobuhiro Abe, and Kunihiro Sumoto*

*Faculty of Pharmaceutical Sciences, Fukuoka University; Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan

Abstract

New oxazolidin-2-ones (3), which mimic the clinically useful antibacterial agent (1) (Linezolid) were prepared by using a cyclization procedure with diethyl carbonate from aminoalcohol (7) starting with DL-serine methyl ester hydrochloride (4) and aromatic carboxylic acid derivatives (5).