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Paper | Regular issue | Vol 75, No. 8, 2008, pp.1953-1961
Published online, 11th April, 2008
DOI: 10.3987/COM-08-11365
Synthesis of New Thiazolo[3,2-a]pyrimidin-5-one Derivatives in Reaction of 3-Allyl-2-thiouracils Cyclization

Renata Studzinska, Marcin Wróblewski, and Marcin Draminski*

*Department of General Chemistry, Nicolaus Copernicus University in Torun, Collegium Medicum in Bydgoszcz, ul. Debowa 3, 85-626 Bydgoszcz, Poland

Abstract

The series of thiazolo[3,2-a]pyrimidin-5-one derivatives in cyclization reaction of 3-allyl-2-thiouracil derivatives with iodine monochloride, and then hydrogen iodide elimination from intermediate reaction product has been obtained. On the basis of the studies of reaction kinetics, the elimination reaction mechanism has been proposed. Moreover, the influence of substituent on the reaction elimination rate has been investigated.