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Note | Regular issue | Vol 75, No. 8, 2008, pp.2043-2061
Published online, 14th April, 2008
DOI: 10.3987/COM-08-11377
Conformationally Constrained Adamantaneoxazolines of Pharmacological Interest

Ioannis Papanastasiou, George B. Foscolos,* Andrew Tsotinis, Judit Oláh, Judit Ovádi, S. Radhika Prathalingam, and John Kelly

*Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens GR-15771, Greece

Abstract

New conformationally constrained adamantane 2-oxazoline building blocks 1-4 were synthesized and their antimicrotubule and antitrypanosomal potency was investigated. Although most of the new compounds affect tubulin polymerization, this does not make a major contribution to trypanocidal activity.